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KMID : 0380620210530020165
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Korean Journal of Food Science and Technology
2021 Volume.53 No. 2 p.165 ~ p.173
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Inhibitory effect of ethanol extract of Codonopsis lanceolata against oxidative stress and disruption of tight cell junction in NCI-H441 cells after exposure to urban particulate matter
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So Hee-Jung
Chun Su-Hyun
Lee Jin-Won
Lee Kwang-Won
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Abstract
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One of the major sources of air pollution is urban particulate matter (UPM), which causes lung diseases involving oxidative stress, inflammation, and cancer. Codonopsis lanceolata (CL) has been used in East Asia as a traditional oriental medicinal ingredient for lung diseases (e.g., asthma and bronchitis). However, the connection between the impact of CL and UPM in the lungs has rarely been investigated. This study aimed to confirm the inhibitory activity of the ethanol extract of CL (ECL) against oxidative stress and disruption of tight cell junctions in human pulmonary epithelial cells after exposure to UPM. As the lung cells were pre-treated with ECL, the UPM-induced increase in cellular reactive oxygen species production suppressed tight junction proteins (e.g., N-cadherin, fibronectin, occludin, zonula occludens-1, and claudin-4). These results suggest that ECL prevents the possible effects of UPM toxicity on the lungs.
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KEYWORD
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Urban particulate matter, oxidative stress, Codonopsis lanceolata, antioxidant, tight junction
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